Comparison of the macrofilaricidal efficacy of oxfendazole and its isomers against the rodent filaria Litomosoides sigmodontis

by Risch F, Koschel M, Lenz B, Specht S,  Hoerauf A, Hübner MP, Scandale I. Frontiers in Tropical Diseases 2022; doi: 10.3389/fitd.2022.982421

Summary: Originally developed for the veterinary market, oxfendazole is a lead macrofilaricidal candidate for the treatment of onchocerciasis and lymphatic filariasis. The authors of this study compared the efficacy of oxfendazole isomers with the commercially available racemic mixture Dolthene in a mouse model of filariasis using Litomosoides sigmodontis. Overall, the results suggest that both oxfendazole isomers have similar anti-filarial activity and do not support the development of a single isomer for future use in human patients.

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