The long and winding road towards new treatments against lymphatic filariasis and onchocerciasis

by Risch F, Kazakov A, Specht S, Pfarr K, Fischer PU, Hoerauf A, Hübner MP. Trends in Parasitology 2024. doi: 10.1016/j.pt.2024.07.005 1

Summary: Although lymphatic filariasis and onchocerciasis have been targeted for global elimination, these helminth infections are still a major public health problem across the tropics and subtropics. Despite decades of research, treatment options remain limited; drugs that both completely clear infection and that can be used on a large scale, are still unavailable. In this review, the authors discuss the strengths and weaknesses of currently available treatments and new ones in development, concluding that the preclinical R&D pipeline for filarial infections continues to be limited and highlighting the importance of continuous drug discovery and testing.

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