{"id":14311,"date":"2024-01-11T14:52:00","date_gmt":"2024-01-11T14:52:00","guid":{"rendered":"https:\/\/dndial.org\/projetos\/triagem-copy\/"},"modified":"2026-04-20T19:00:24","modified_gmt":"2026-04-20T19:00:24","slug":"dndi-6148","status":"publish","type":"projetos","link":"https:\/\/dndial.org\/es\/projetos\/dndi-6148\/","title":{"rendered":"DNDI-6148"},"content":{"rendered":"<div id=\"abertura-pagina-projeto-block_627ea80e8856a\" class=\"abertura-pagina-projeto\">\n        \n                    <div class=\"tarja-color pt-20  pb-60\" style=\"background:#0080a5;\">\n                <div class=\"container\">\n            <div class=\"row\">\n                <div class=\"col-lg-12\">\n                    <div class=\"breadcrumb mt-4 mb-5 futura font-12 text-white text-uppercase fw-bold no-print\">\n                        <a href=\"https:\/\/dndial.org\/es\/\" rel=\"nofollow\">Home<\/a> &nbsp;&nbsp;&#187;&nbsp;&nbsp; <a href=\"https:\/\/dndial.org\/es\/nuestros-proyectos\/\">Nuestros proyectos<\/a> &nbsp;&nbsp;&#187;&nbsp;&nbsp; DNDI-6148<\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n                <div class=\"container\">\n            <div class=\"row\">\n                <div class=\"col-lg-8 offset-lg-2\">\n                    <div class=\"align-items-center d-flex flex-row\">\n                                                <div class=\"icone\">\n                            <img decoding=\"async\" src=\"https:\/\/dndial.org\/wp-content\/uploads\/2022\/01\/icon-chagas_site_global.svg\"\n                                alt=\"Enfermedad de Chagas\" class=\"\">\n                        <\/div>\n                                                <div class=\"text-content\">\n                            <small class=\"font-20 din mb-0\">\n                                <a href=\"https:\/\/dndial.org\/es\/doencas\/doenca-de-chagas\/\">\n                                    Enfermedad de Chagas                                    <\/a><\/small>\n                            <h1 class=\"text-white font-36 fw-bold futura mt-0 lh-2\">\n                                DNDI-6148<\/h1>\n                        <\/div>\n                    <\/div>\n                    <div class=\"col-xl-12 social align-self-center text-end\">\n                                                <a href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https:\/\/dndial.org\/es\/projetos\/dndi-6148\/\" target=\"_blank\">\n                            <i class=\"fab fa-facebook-f\"><\/i><\/a>\n                                                                        <a href=\"https:\/\/twitter.com\/intent\/tweet?text=DNDI-6148 - https:\/\/dndial.org\/es\/projetos\/dndi-6148\/\"\n                            target=\"_blank\">\n                            <i class=\"fa-brands fa-x-twitter\"><\/i><\/a>\n                                                                        <a href=\"https:\/\/www.linkedin.com\/shareArticle?mini=true&#038;url=https:\/\/dndial.org\/es\/projetos\/dndi-6148\/&#038;title=DNDI-6148\"\n                            target=\"_blank\">\n                            <i class=\"fab fa-linkedin-in\"><\/i><\/a>\n                                                                                                                        <a href=\"mailto:?subject=DNDI-6148 | DNDi&amp;body= - https:\/\/dndial.org\/es\/projetos\/dndi-6148\/\"\n                            title=\"Compartilhar por e-mail\">\n                                                    <\/a>\n                        <a href=\"javascript:if(window.print)window.print()\" title=\"Imprimir essa p\u00e1gina\"><i\n                                class=\"fas fa-print\"><\/i><\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"container mt-80 mb-80\">\n        <div class=\"row\">\n\n            <div class=\"col-lg-8 offset-lg-2\">\n                <div class=\"row\">\n                                                            <div class=\"col-lg-3\">\n                        <h3 class=\"futura font-20 fw-bold\" style=\"color:#0080a5\">\n                            Inicio del proyecto<\/h3>\n                        <span class=\"din font-20\">2019<\/span>\n                    <\/div>\n                                                                                                    <div class=\"col-lg-3\">\n                        <h3 class=\"futura font-20 fw-bold\" style=\"color:#0080a5\">\n                            Actualizado el<\/h3>\n                        <span class=\"din font-20\">15 de febrero de 2023<\/span>\n                    <\/div>\n                                    <\/div>\n                                <h3 class=\"futura font-20 fw-bold mt-4\" style=\"color:#0080a5\">\n                    Fase actual de desarrollo de f\u00e1rmacos                <\/h3>\n                                <div class=\"row justify-content-start fases\">\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_01 \">\n                            Discovery                        <\/div>\n                    <\/div>\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_02 fase-destaque\">\n                            Pesquisa Translacional                        <\/div>\n                    <\/div>\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_03 \">\n                            Ensaios Cl\u00ednicos                        <\/div>\n                    <\/div>\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_04 \">\n                            Registro e Acesso                        <\/div>\n                    <\/div>\n                                    <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n        <\/div>\n<script>\n$(document).ready(function() {\n    if (window.location.href.indexOf(\"\/es\/\") > -1) {\n        $(\".fase:contains('Registro e Acesso')\").html(\"Registro y Acceso\");\n        $(\".fase:contains('Ensaios Cl\u00ednicos')\").html(\"Ensayos cl\u00ednicos\");\n        $(\".fase:contains('Pesquisa Translacional')\").html(\"Investigaci\u00f3n traslacional\");\n        $(\".fase:contains('Discovery')\").html(\"Descubrimiento de f\u00e1rmacos\");\n    }\n});\n<\/script>\n\n            <div id=\"titulo-e-texto-block_6283aaccbd02f\"\n    class=\"titulo-e-texto bg-grey-02 pt-90 pb-100\">\n    <div class=\"container\">\n        <div class=\"row\">\n            <div class=\"col-lg-8 offset-lg-2\">\n                <h2 class=\"futura fw-bold lh-base font-20 mb-4\">\n                                    <\/h2>\n                                <p>&nbsp;<\/p>\n<p>Hay una urgente necesidad de nuevos tratamientos que se puedan usar para las fases aguda y cr\u00f3nica de la enfermedad de Chagas y que sean m\u00e1s seguros y eficaces que los reg\u00edmenes de tratamiento actuales, que utilizan benznidazol y nifurtimox.<\/p>\n<p>El oxaborol DNDI-6148 surgi\u00f3 como un candidato prometedor para la leishmaniasis visceral y la leishmaniasis cut\u00e1nea.\u00a0 Tambi\u00e9n ha demostrado eficacia contra la enfermedad de Chagas en un modelo <em>in vivo <\/em>y se est\u00e1 evaluando su potencial para seguir adelante con su desarrollo.<\/p>\n<p>&nbsp;<\/p>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n        <div id=\"accordion-block_65a80f1da2f89\"\n      class=\"accordion bg-bege  \">\n      <div class=\"container\">\n          <div class=\"row\">\n              <div class=\"col-lg-8 offset-lg-2\">\n                  <h2 class=\"futura orange-01 lh-base fw-bold font-36\">\n                      Actualizaciones de proyectos<\/h2>\n              <\/div>\n          <\/div>\n      <\/div>\n      <div id=\"accordion\">\n          <div class=\"accordion\" id=\"accordionExample\">\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_65a80f1da2f891\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_65a80f1da2f891\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_65a80f1da2f891\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2025<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_65a80f1da2f891\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_65a80f1da2f891\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Las actividades relacionadas con el desarrollo cl\u00ednico de DNDI-6148 permanecieron suspendidas.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_65a80f1da2f892\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_65a80f1da2f892\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_65a80f1da2f892\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2024<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_65a80f1da2f892\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_65a80f1da2f892\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Las actividades relacionadas con el desarrollo cl\u00ednico de DNDI-6148 permanecieron suspendidas.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_65a80f1da2f893\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_65a80f1da2f893\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_65a80f1da2f893\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2023<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_65a80f1da2f893\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_65a80f1da2f893\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>El desarrollo de DNDI-6148 ha sido pausado a la espera de m\u00e1s estudios para determinar el potencial de toxicidad reproductiva. Debido a sus posibles efectos teratog\u00e9nicos, los tratamientos actuales para la enfermedad de Chagas \u2013 benznidazol y nifurtimox \u2013 no pueden ser utilizados por mujeres embarazadas o que puedan quedar embarazadas. Junto con sus socios, DNDi est\u00e1 realizando evaluaciones precl\u00ednicas de varios oxaboroles para seleccionar el mejor candidato para su posterior desarrollo.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_65a80f1da2f894\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_65a80f1da2f894\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_65a80f1da2f894\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2022<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_65a80f1da2f894\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_65a80f1da2f894\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>La \u00faltima cohorte del primer estudio en humanos se finaliz\u00f3 en el primer trimestre de 2022. Se demostr\u00f3 que el DNDI-6148 es seguro y bien tolerado despu\u00e9s de una \u00fanica dosis oral. La preparaci\u00f3n para el estudio de Fase I con dosis m\u00faltiples ascendentes en la India se inici\u00f3 en paralelo con otras investigaciones toxicol\u00f3gicas reproductivas.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_65a80f1da2f895\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_65a80f1da2f895\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_65a80f1da2f895\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2021<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_65a80f1da2f895\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_65a80f1da2f895\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Despu\u00e9s de un retraso debido a la pandemia de COVID-19, un estudio de Fase I con dosis \u00fanica ascendente de DNDI-6148 avanz\u00f3 en 2021 y terminar\u00e1 en el primer trimestre de 2022. Los resultados preliminares respaldan la progresi\u00f3n a un estudio de dosis m\u00faltiples ascendentes, que comenzar\u00e1 en 2022.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_65a80f1da2f896\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_65a80f1da2f896\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_65a80f1da2f896\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2020<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_65a80f1da2f896\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_65a80f1da2f896\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Se llev\u00f3 a cabo un an\u00e1lisis completo de datos farmacocin\u00e9ticos, farmacodin\u00e1micos y de modelizaci\u00f3n para determinar el potencial de desarrollo del DNDI-6148, tras su nominaci\u00f3n como candidato cl\u00ednico para la enfermedad de Chagas en 2020. Una vez que est\u00e9n disponibles los datos de los estudios de Fase I en humanos (retrasados por la pandemia de COVID-19), se finalizar\u00e1 el an\u00e1lisis.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                        <\/div>\n      <\/div>\n  <\/div>\n\n                <div id=\"block-links-block_633ade17c91a6\"\n      class=\"block-links bg-white pt-70 pb-40\">\n      <div class=\"container\">\n          <div class=\"row\">\n              <div class=\"col-lg-8 offset-lg-2\">\n                  <h2 class=\"futura fw-bold font-36 lh-base mb-4\">\n                      Socios y proveedores de servicios                   <\/h2>\n                                    <ul class=\"list-unstyled\">\n                                            <li class=\"din font-20\">\n                                                    <i class=\"fas fa-arrow-right orange-01 me-2 font-16\"><\/i> <a\n                              href=\"https:\/\/dndi.org\/research-development\/portfolio\/dndi-6148-chagas\/\" target=\"_blank\">\n                              Ver la lista completa<\/a>\n                                                <\/li>\n                                        <\/ul>\n                                <\/div>\n          <\/div>\n      <\/div>\n  <\/div>\n\n            <div id=\"block-links-block_633b3b3c2f2ea\"\n      class=\"block-links bg-white  pb-60\">\n      <div class=\"container\">\n          <div class=\"row\">\n              <div class=\"col-lg-8 offset-lg-2\">\n                  <h2 class=\"futura fw-bold font-36 lh-base mb-4\">\n                      Financiaci\u00f3n                  <\/h2>\n                                    <ul class=\"list-unstyled\">\n                                            <li class=\"din font-20\">\n                                                    <i class=\"fas fa-arrow-right orange-01 me-2 font-16\"><\/i> <a\n                              href=\"https:\/\/dndi.org\/research-development\/portfolio\/dndi-6148-chagas\/\" target=\"_blank\">\n                              Ver la lista completa<\/a>\n                                                <\/li>\n                                        <\/ul>\n                                <\/div>\n          <\/div>\n      <\/div>\n  <\/div>","protected":false},"author":1,"parent":0,"template":"","meta":{"inline_featured_image":false,"_links_to":"","_links_to_target":""},"class_list":["post-14311","projetos","type-projetos","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/dndial.org\/es\/wp-json\/wp\/v2\/projetos\/14311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dndial.org\/es\/wp-json\/wp\/v2\/projetos"}],"about":[{"href":"https:\/\/dndial.org\/es\/wp-json\/wp\/v2\/types\/projetos"}],"author":[{"embeddable":true,"href":"https:\/\/dndial.org\/es\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":17,"href":"https:\/\/dndial.org\/es\/wp-json\/wp\/v2\/projetos\/14311\/revisions"}],"predecessor-version":[{"id":18073,"href":"https:\/\/dndial.org\/es\/wp-json\/wp\/v2\/projetos\/14311\/revisions\/18073"}],"wp:attachment":[{"href":"https:\/\/dndial.org\/es\/wp-json\/wp\/v2\/media?parent=14311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}