{"id":9828,"date":"2022-09-06T16:30:09","date_gmt":"2022-09-06T16:30:09","guid":{"rendered":"https:\/\/www.dndial.org\/?post_type=projetos&#038;p=9828"},"modified":"2026-03-13T13:16:18","modified_gmt":"2026-03-13T13:16:18","slug":"cpg-d35-dndi-2319","status":"publish","type":"projetos","link":"https:\/\/dndial.org\/es\/projetos\/cpg-d35-dndi-2319\/","title":{"rendered":"CpG-D35 (DNDI-2319)"},"content":{"rendered":"<div id=\"abertura-pagina-projeto-block_62aa25c2dca05\" class=\"abertura-pagina-projeto\">\n        \n                    <div class=\"tarja-color pt-20  pb-60\" style=\"background:#f4ba00;\">\n                <div class=\"container\">\n            <div class=\"row\">\n                <div class=\"col-lg-12\">\n                    <div class=\"breadcrumb mt-4 mb-5 futura font-12 text-white text-uppercase fw-bold no-print\">\n                        <a href=\"https:\/\/dndial.org\/es\/\" rel=\"nofollow\">Home<\/a> &nbsp;&nbsp;&#187;&nbsp;&nbsp; <a href=\"https:\/\/dndial.org\/es\/nuestros-proyectos\/\">Nuestros proyectos<\/a> &nbsp;&nbsp;&#187;&nbsp;&nbsp; CpG-D35 (DNDI-2319)<\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n                <div class=\"container\">\n            <div class=\"row\">\n                <div class=\"col-lg-8 offset-lg-2\">\n                    <div class=\"align-items-center d-flex flex-row\">\n                                                <div class=\"icone\">\n                            <img decoding=\"async\" src=\"https:\/\/dndial.org\/wp-content\/uploads\/2022\/02\/icon_leish.svg\"\n                                alt=\"Leishmaniasis cut\u00e1nea\" class=\"\">\n                        <\/div>\n                                                <div class=\"text-content\">\n                            <small class=\"font-20 din mb-0\">\n                                <a href=\"https:\/\/dndial.org\/es\/doencas\/leishmaniasis-cutanea\/\">\n                                    Leishmaniasis cut\u00e1nea                                    <\/a><\/small>\n                            <h1 class=\"text-white font-36 fw-bold futura mt-0 lh-2\">\n                                CpG-D35 (DNDI-2319)<\/h1>\n                        <\/div>\n                    <\/div>\n                    <div class=\"col-xl-12 social align-self-center text-end\">\n                                                <a href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https:\/\/dndial.org\/es\/projetos\/cpg-d35-dndi-2319\/\" target=\"_blank\">\n                            <i class=\"fab fa-facebook-f\"><\/i><\/a>\n                                                                        <a href=\"https:\/\/twitter.com\/intent\/tweet?text=CpG-D35 (DNDI-2319) - https:\/\/dndial.org\/es\/projetos\/cpg-d35-dndi-2319\/\"\n                            target=\"_blank\">\n                            <i class=\"fa-brands fa-x-twitter\"><\/i><\/a>\n                                                                        <a href=\"https:\/\/www.linkedin.com\/shareArticle?mini=true&#038;url=https:\/\/dndial.org\/es\/projetos\/cpg-d35-dndi-2319\/&#038;title=CpG-D35 (DNDI-2319)\"\n                            target=\"_blank\">\n                            <i class=\"fab fa-linkedin-in\"><\/i><\/a>\n                                                                                                                        <a href=\"mailto:?subject=CpG-D35 (DNDI-2319) | DNDi&amp;body= - https:\/\/dndial.org\/es\/projetos\/cpg-d35-dndi-2319\/\"\n                            title=\"Compartilhar por e-mail\">\n                                                    <\/a>\n                        <a href=\"javascript:if(window.print)window.print()\" title=\"Imprimir essa p\u00e1gina\"><i\n                                class=\"fas fa-print\"><\/i><\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <div class=\"container mt-80 mb-80\">\n        <div class=\"row\">\n\n            <div class=\"col-lg-8 offset-lg-2\">\n                <div class=\"row\">\n                                                            <div class=\"col-lg-3\">\n                        <h3 class=\"futura font-20 fw-bold\" style=\"color:#f4ba00\">\n                            Inicio del proyecto<\/h3>\n                        <span class=\"din font-20\">2014<\/span>\n                    <\/div>\n                                                                                                    <div class=\"col-lg-3\">\n                        <h3 class=\"futura font-20 fw-bold\" style=\"color:#f4ba00\">\n                            Actualizado el<\/h3>\n                        <span class=\"din font-20\">16 de febrero de 2023<\/span>\n                    <\/div>\n                                    <\/div>\n                                <h3 class=\"futura font-20 fw-bold mt-4\" style=\"color:#f4ba00\">Objetivo                <\/h3>\n                <span class=\"din font-20\"> Demostrar la adecuaci\u00f3n de un inmunomodulador para estimular el sistema inmunol\u00f3gico innato para combatir la infecci\u00f3n parasitaria responsable por la leishmaniasis cut\u00e1nea.<\/span>\n                                <h3 class=\"futura font-20 fw-bold mt-4\" style=\"color:#f4ba00\">\n                    Fase actual de desarrollo de f\u00e1rmacos                <\/h3>\n                                <div class=\"row justify-content-start fases\">\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_01 \">\n                            Discovery                        <\/div>\n                    <\/div>\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_02 fase-destaque\">\n                            Pesquisa Translacional                        <\/div>\n                    <\/div>\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_03 \">\n                            Ensaios Cl\u00ednicos                        <\/div>\n                    <\/div>\n                                        <div class=\"col-lg-3 mb-4\">\n                        <div\n                            class=\"fase futura font-12 text-uppercase fw-bold fase_04 \">\n                            Registro e Acesso                        <\/div>\n                    <\/div>\n                                    <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n\n        <\/div>\n<script>\n$(document).ready(function() {\n    if (window.location.href.indexOf(\"\/es\/\") > -1) {\n        $(\".fase:contains('Registro e Acesso')\").html(\"Registro y Acceso\");\n        $(\".fase:contains('Ensaios Cl\u00ednicos')\").html(\"Ensayos cl\u00ednicos\");\n        $(\".fase:contains('Pesquisa Translacional')\").html(\"Investigaci\u00f3n traslacional\");\n        $(\".fase:contains('Discovery')\").html(\"Descubrimiento de f\u00e1rmacos\");\n    }\n});\n<\/script>\n\n            <div id=\"titulo-e-texto-block_62aa2619dca06\"\n    class=\"titulo-e-texto bg-grey-02 pt-90 pb-100\">\n    <div class=\"container\">\n        <div class=\"row\">\n            <div class=\"col-lg-8 offset-lg-2\">\n                <h2 class=\"futura fw-bold lh-base font-20 mb-4\">\n                                    <\/h2>\n                                <p>Se est\u00e1 desarrollando el CpG-D35 como una terapia combinada para el tratamiento de la leishmaniasis cut\u00e1nea complicada a trav\u00e9s de una alianza con GeneDesign, una compa\u00f1\u00eda de Ajinomoto, y la Universidad de Tokio. Los par\u00e1sitos <i>Leishmania<\/i> son capaces de eludir o explotar los mecanismos inmunol\u00f3gicos y persistir en c\u00e9lulas hospederas. La modulaci\u00f3n de la respuesta inmune con oligonucle\u00f3tidos CpG puede mejorar la eficacia de las quimioterapias. Este proyecto tiene como objetivo producir un inmunomodulador para estimular el sistema inmune innato y combatir la infecci\u00f3n parasitaria de manera complementaria a la terapia con medicamentos.<\/p>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n                <div id=\"accordion-block_62a8b47fb3203\"\n      class=\"accordion bg-bege pt-80 pb-80\">\n      <div class=\"container\">\n          <div class=\"row\">\n              <div class=\"col-lg-8 offset-lg-2\">\n                  <h2 class=\"futura orange-01 lh-base fw-bold font-36\">\n                      Actualizaciones del proyecto<\/h2>\n              <\/div>\n          <\/div>\n      <\/div>\n      <div id=\"accordion\">\n          <div class=\"accordion\" id=\"accordionExample\">\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32031\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32031\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32031\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2024<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32031\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32031\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>El estudio de dosis m\u00faltiples ascendentes se detuvo por falta de eficacia despu\u00e9s de la inscripci\u00f3n de seis participantes. Cuatro participantes recibieron CpG-D35; dos recibieron miltefosina. Todos los eventos adversos reportados fueron leves o moderados y no requirieron la interrupci\u00f3n del tratamiento. Las dificultades de reclutamiento estuvieron relacionadas con la necesidad de hospitalizaci\u00f3n y criterios de inclusi\u00f3n y exclusi\u00f3n particularmente restrictivos. Los esfuerzos en curso buscan simplificar el protocolo y los procedimientos del estudio, as\u00ed como ampliar el grupo de participantes potenciales.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32032\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32032\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32032\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2023<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32032\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32032\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>El protocolo del estudio de Fase I de dosis m\u00faltiples ascendentes fue aprobado por las autoridades regulatorias colombianas en junio de 2023, lo que permiti\u00f3 la importaci\u00f3n de los medicamentos del estudio y la organizaci\u00f3n de la visita de inicio del sitio de estudio, que se llev\u00f3 a cabo en julio de 2023. El proceso de selecci\u00f3n de participantes potenciales comenz\u00f3 en septiembre. Aunque 42 posibles participantes fueron preseleccionados a finales de diciembre, el n\u00famero de sujetos que cumpl\u00edan con los criterios de inscripci\u00f3n estuvo por debajo de las expectativas. Se est\u00e1 desarrollando una enmienda al protocolo del estudio que tiene como objetivo agilizar la inscripci\u00f3n y completar el estudio a finales de 2024.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32033\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32033\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32033\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2022<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32033\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32033\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>La Organizaci\u00f3n Panamericana de la Salud public\u00f3, en junio de 2022, nuevas directrices para el tratamiento de la leishmaniasis visceral en las Am\u00e9ricas, poniendo fin efectivamente al tratamiento con antimoniales pentavalentes a favor de medicamentos menos t\u00f3xicos. Las nuevas directrices recomiendan el uso de anfotericina B liposomal como tratamiento de primera l\u00ednea para la enfermedad.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32034\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32034\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32034\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2021<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32034\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32034\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Tras la finalizaci\u00f3n de los estudios toxicol\u00f3gicos precl\u00ednicos en 2020, el estudio del CpG-D35 avanz\u00f3 en 2021 hacia el primer ensayo cl\u00ednico en humanos. Una vez que las actividades de qu\u00edmica, fabricaci\u00f3n y control se desarrollaron de acuerdo al plan, se inici\u00f3 y complet\u00f3 un estudio de dosis \u00fanica ascendente en voluntarios sanos en el Reino Unido. De un modo general, se constat\u00f3 que el CpG-D35 es bien tolerado y seguro, y no se cumpli\u00f3 ninguno de los criterios para interrumpir el aumento de la dosis. Con base en estos resultados, se est\u00e1n llevando a cabo los preparativos para realizar un estudio de dosis m\u00faltiples ascendentes en pacientes con leishmaniasis cut\u00e1nea.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32035\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32035\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32035\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2020<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32035\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32035\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Los estudios toxicol\u00f3gicos precl\u00ednicos se concluyeron a fines de 2020 y demostraron la adecuaci\u00f3n de CpG-D35 para avanzar a los primeros ensayos cl\u00ednicos en humanos. El desarrollo cl\u00ednico y farmac\u00e9utico continuar\u00e1 con el apoyo del Global Health Innovative Technology Fund (Fondo GHIT), de Jap\u00f3n, con el inicio de un estudio de dosis \u00fanica ascendente en voluntarios sanos previsto para mediados de 2021 en el Reino Unido.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32036\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32036\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32036\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2019<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32036\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32036\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Los estudios toxicol\u00f3gicos precl\u00ednicos se iniciaron en 2019 y deben ser concluidos a mediados de 2020. De ser positivos los resultados, la DND<i>i<\/i> espera iniciar un primer estudio de Fase I en humanos hasta fines de 2020.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32037\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32037\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32037\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2018<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32037\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32037\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>En 2019 se realizar\u00e1 un paquete precl\u00ednico para posibilitar un primer estudio en humanos (Fase I). Se planea una reuni\u00f3n con la Agencia Reguladora de Medicamentos y Productos Sanitarios del Reino Unido para 2019 para discutir el plan de desarrollo precl\u00ednico y el paquete cl\u00ednico.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32038\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32038\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32038\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2017<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32038\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32038\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Los resultados finales del estudio precl\u00ednico de eficacia in vivo mostraron un mejor resultado para CpG-D35, ya sea solo o en combinaci\u00f3n con antimonial pentavalente (glucantime). Estos resultados respaldaron la finalizaci\u00f3n del paquete precl\u00ednico y el inicio de la preparaci\u00f3n de suministros cl\u00ednicos para un estudio de Fase I.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb32039\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb32039\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb32039\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2016<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb32039\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb32039\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>En 2016 se iniciaron dos estudios, uno in vitro y otro in vivo. El estudio in vivo tiene como objetivo demostrar si el CpG-D35, ya sea solo o en combinaci\u00f3n con quimioterapia antimonial, conducir\u00e1 a mejores resultados contra la infecci\u00f3n por Leishmania en comparaci\u00f3n con antimoniales solos. Los resultados se esperan para mediados de 2017. El estudio in vitro tiene como objetivo evaluar la capacidad estimulante de CpG-D35 tanto en c\u00e9lulas mononucleares de sangre perif\u00e9rica como en muestras de sangre total de pacientes con leishmaniasis cut\u00e1nea, debido a diferentes especies de Leishmania, y pacientes con PKDL, y determinar qu\u00e9 genes del hospedero son modulados en estas dos condiciones. Los resultados se esperan para finales de 2017.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                            \n              <div class=\"accordion-item\">\n                  <h3 class=\"accordion-header\" id=\"heading-accordion-block_62a8b47fb320310\">\n                      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\"\n                          data-bs-target=\"#collapse-accordion-block_62a8b47fb320310\" aria-expanded=\"false\"\n                          aria-controls=\"collapse-accordion-block_62a8b47fb320310\">\n                          <div class=\"container\">\n                              <div class=\"row\">\n                                  <div class=\"col-lg-8 offset-lg-2\">\n                                      <span class=\"d-flex\">\n                                          <div class=\"futura\">2015<\/div>\n                                          <i class=\"fas fa-chevron-down ms-auto align-self-center\"><\/i>\n                                      <\/span>\n                                  <\/div>\n                              <\/div>\n                          <\/div>\n                      <\/button>\n                  <\/h3>\n              <\/div>\n              <div id=\"collapse-accordion-block_62a8b47fb320310\"\n                  class=\"accordion-collapse animate__animated animate__fadeIn collapse\"\n                  aria-labelledby=\"heading-accordion-block_62a8b47fb320310\" data-bs-parent=\"#accordionExample\">\n                  <div class=\"accordion-body\">\n                      <div class=\"container\">\n                          <div class=\"row\">\n                              <div class=\"col-lg-8 offset-lg-2\">\n                                  <p>Se identificaron los requisitos previos de seguridad precl\u00ednica y los proveedores de servicios para permitir el IND y la entrada en los ensayos cl\u00ednicos de prueba de concepto de Fase I.<\/p>\n                              <\/div>\n                          <\/div>\n                      <\/div>\n                  <\/div>\n              <\/div>\n                        <\/div>\n      <\/div>\n  <\/div>\n\n                <div id=\"block-links-block_6328b340c76b0\"\n      class=\"block-links bg-grey-03 pt-70 pb-60\">\n      <div class=\"container\">\n          <div class=\"row\">\n              <div class=\"col-lg-8 offset-lg-2\">\n                  <h2 class=\"futura fw-bold font-36 lh-base mb-4\">\n                      Noticias y notas de prensa                  <\/h2>\n                                    <ul class=\"list-unstyled\">\n                                            <li class=\"din font-20\">\n                                                    <i class=\"fas fa-arrow-right orange-01 me-2 font-16\"><\/i> <a\n                              href=\"https:\/\/dndi.org\/scientific-articles\/2020\/plosntds-cpgodnd35-improves-response-abbreviated-low-dose-pentavalent-antimonial-treatment-cutaneous-leishmaniasis\/\" target=\"_blank\">\n                              28 February 2020 &#8211; CpG ODN D35 improves the response to abbreviated low-dose pentavalent antimonial treatment in non-human primate model of cutaneous leishmaniasis, PLOS Neglected Tropical Diseases<\/a>\n                                                <\/li>\n                                            <li class=\"din font-20\">\n                                                    <i class=\"fas fa-arrow-right orange-01 me-2 font-16\"><\/i> <a\n                              href=\"https:\/\/dndi.org\/scientific-articles\/2020\/plosntds-cpgodnd35-improves-response-abbreviated-low-dose-pentavalent-antimonial-treatment-cutaneous-leishmaniasis\/\" target=\"_blank\">\n                              28 February 2020 &#8211; CpG ODN D35 improves the response to abbreviated low-dose pentavalent antimonial treatment in non-human primate model of cutaneous leishmaniasis, PLOS Neglected Tropical Diseases<\/a>\n                                                <\/li>\n                                        <\/ul>\n                                <\/div>\n          <\/div>\n      <\/div>\n  <\/div>\n\n                <div id=\"block-links-block_633ade17c91a6\"\n      class=\"block-links bg-white pt-70 pb-40\">\n      <div class=\"container\">\n          <div class=\"row\">\n              <div class=\"col-lg-8 offset-lg-2\">\n                  <h2 class=\"futura fw-bold font-36 lh-base mb-4\">\n                      Socios y proveedores de servicios                  <\/h2>\n                                    <ul class=\"list-unstyled\">\n                                            <li class=\"din font-20\">\n                                                    <i class=\"fas fa-arrow-right orange-01 me-2 font-16\"><\/i> <a\n                              href=\"https:\/\/dndi.org\/research-development\/portfolio\/cpg-d35\/\" target=\"_blank\">\n                              Ver la lista completa<\/a>\n                                                <\/li>\n                                        <\/ul>\n                                <\/div>\n          <\/div>\n      <\/div>\n  <\/div>\n\n            <div id=\"block-links-block_633b3c39c91a9\"\n      class=\"block-links bg-white  pb-60\">\n      <div class=\"container\">\n          <div class=\"row\">\n              <div class=\"col-lg-8 offset-lg-2\">\n                  <h2 class=\"futura fw-bold font-36 lh-base mb-4\">\n                      Financiaci\u00f3n                  <\/h2>\n                                    <ul class=\"list-unstyled\">\n                                            <li class=\"din font-20\">\n                                                    <i class=\"fas fa-arrow-right orange-01 me-2 font-16\"><\/i> <a\n                              href=\"https:\/\/dndi.org\/research-development\/portfolio\/cpg-d35\/\" target=\"_blank\">\n                              Ver la lista completa<\/a>\n                                                <\/li>\n                                        <\/ul>\n                                <\/div>\n          <\/div>\n      <\/div>\n  <\/div>\n\n    <div id=\"newsletter-block_62584aaf95354\"\n    class=\"newsletter alignfull\">\n    <section id=\"newsletter\"\n        style=\"background-image:url(https:\/\/dndial.org\/wp-content\/uploads\/2022\/01\/newsletter.jpg)\"\n        >\n        <div class=\"container\">\n            <div class=\"row align-items-center\">\n                <div class=\"col-lg-8 offset-lg-2 text-center\">\n                                        <h3 class=\"text-white futura font-40 fw-bold\">Newsletter<\/h3>\n                                                            <p class=\"text-white din font-20\">Obtenga nuestras \u00faltimas noticias, historias, art\u00edculos cient\u00edficos y oportunidades de trabajo.<\/p>\n                    \n                    \n                    <div id=\"mc_embed_shell\">\n                        <link href=\"\/\/cdn-images.mailchimp.com\/embedcode\/classic-061523.css\" rel=\"stylesheet\"\n                            type=\"text\/css\">\n                        <style type=\"text\/css\">\n                        #mce-EMAIL {\n                            padding-top: 8px;\n                            padding-bottom: 8px;\n                        }\n\n                        .form-control {\n                            border-radius: 3px !important;\n                        }\n                        <\/style>\n                        <div id=\"mc_embed_signup\">\n                            <form\n                                action=\"https:\/\/dndi.us1.list-manage.com\/subscribe\/post?u=c34dff283831a286eb9818365&amp;id=4c3dd201d2&amp;SIGNUP=DNDiAL-website\"\n                                method=\"post\" 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class=\"col-md-6\">\n                                            <select name=\"MMERGE7\" class=\"form-select\" id=\"mce-MMERGE7\">\n                                                <option value=\"\" selected disabled>Pa\u00eds<\/option>\n                                                <option value=\"United States of America\">United States of America\n                                                <\/option>\n                                                <option value=\"Aaland Islands\">Aaland Islands<\/option>\n                                                <option value=\"Afghanistan\">Afghanistan<\/option>\n                                                <option value=\"Albania\">Albania<\/option>\n                                                <option value=\"Algeria\">Algeria<\/option>\n                                                <option value=\"American Samoa\">American Samoa<\/option>\n                                                <option value=\"Andorra\">Andorra<\/option>\n                                                <option value=\"Angola\">Angola<\/option>\n                                                <option value=\"Anguilla\">Anguilla<\/option>\n                                                <option value=\"Antarctica\">Antarctica<\/option>\n                                                <option value=\"Antigua And Barbuda\">Antigua And Barbuda<\/option>\n                                                <option value=\"Argentina\">Argentina<\/option>\n                                                <option value=\"Armenia\">Armenia<\/option>\n                                                <option value=\"Aruba\">Aruba<\/option>\n                                                <option value=\"Australia\">Australia<\/option>\n                                                <option value=\"Austria\">Austria<\/option>\n                                                <option value=\"Azerbaijan\">Azerbaijan<\/option>\n                                                <option value=\"Bahamas\">Bahamas<\/option>\n                                                <option value=\"Bahrain\">Bahrain<\/option>\n                                                <option value=\"Bangladesh\">Bangladesh<\/option>\n                                                <option value=\"Barbados\">Barbados<\/option>\n                                                <option value=\"Belarus\">Belarus<\/option>\n                                                <option value=\"Belgium\">Belgium<\/option>\n                                                <option value=\"Belize\">Belize<\/option>\n                                                <option value=\"Benin\">Benin<\/option>\n                                                <option value=\"Bermuda\">Bermuda<\/option>\n                                                <option value=\"Bhutan\">Bhutan<\/option>\n                                                <option value=\"Bolivia\">Bolivia<\/option>\n                                                <option value=\"Bonaire, Saint Eustatius and Saba\">Bonaire, Saint\n                                                    Eustatius\n                                                    and Saba<\/option>\n                                                <option value=\"Bosnia and Herzegovina\">Bosnia and Herzegovina<\/option>\n                                                <option value=\"Botswana\">Botswana<\/option>\n                                                <option value=\"Bouvet Island\">Bouvet Island<\/option>\n                                                <option value=\"Brazil\">Brazil<\/option>\n                                                <option value=\"British Indian Ocean Territory\">British Indian Ocean\n                                                    Territory<\/option>\n                                                <option value=\"Brunei Darussalam\">Brunei Darussalam<\/option>\n                                                <option value=\"Bulgaria\">Bulgaria<\/option>\n                                                <option value=\"Burkina Faso\">Burkina Faso<\/option>\n                                                <option value=\"Burundi\">Burundi<\/option>\n                                                <option value=\"Cambodia\">Cambodia<\/option>\n                                                <option value=\"Cameroon\">Cameroon<\/option>\n                                                <option value=\"Canada\">Canada<\/option>\n                                                <option value=\"Cape Verde\">Cape Verde<\/option>\n                                                <option value=\"Cayman Islands\">Cayman Islands<\/option>\n                                                <option value=\"Central African Republic\">Central African Republic\n                                                <\/option>\n                                                <option value=\"Chad\">Chad<\/option>\n                                                <option value=\"Chile\">Chile<\/option>\n                                                <option value=\"China\">China<\/option>\n                                                <option value=\"Christmas Island\">Christmas Island<\/option>\n                                                <option value=\"Cocos (Keeling) Islands\">Cocos (Keeling) Islands<\/option>\n                                                <option value=\"Colombia\">Colombia<\/option>\n                                                <option value=\"Comoros\">Comoros<\/option>\n                                                <option value=\"Congo\">Congo<\/option>\n                                                <option value=\"Congo, Democratic Republic of the\">Congo, Democratic\n                                                    Republic\n                                                    of the<\/option>\n                                                <option value=\"Cook Islands\">Cook Islands<\/option>\n                                                <option value=\"Costa Rica\">Costa Rica<\/option>\n                                                <option value=\"Cote D'Ivoire\">Cote D&#8217;Ivoire<\/option>\n                                                <option value=\"Croatia\">Croatia<\/option>\n                                                <option value=\"Cuba\">Cuba<\/option>\n                                                <option value=\"Curacao\">Curacao<\/option>\n                                                <option value=\"Cyprus\">Cyprus<\/option>\n                                                <option value=\"Czech Republic\">Czech Republic<\/option>\n                                                <option value=\"Denmark\">Denmark<\/option>\n                                                <option value=\"Djibouti\">Djibouti<\/option>\n                                                <option value=\"Dominica\">Dominica<\/option>\n                                                <option value=\"Dominican Republic\">Dominican Republic<\/option>\n                                                <option value=\"Ecuador\">Ecuador<\/option>\n                                                <option value=\"Egypt\">Egypt<\/option>\n                                                <option value=\"El Salvador\">El Salvador<\/option>\n                                                <option value=\"Equatorial Guinea\">Equatorial Guinea<\/option>\n                                                <option value=\"Eritrea\">Eritrea<\/option>\n                                                <option value=\"Estonia\">Estonia<\/option>\n                                                <option value=\"Ethiopia\">Ethiopia<\/option>\n                                                <option value=\"Falkland Islands\">Falkland Islands<\/option>\n                                                <option value=\"Faroe Islands\">Faroe Islands<\/option>\n                                                <option value=\"Fiji\">Fiji<\/option>\n                                                <option value=\"Finland\">Finland<\/option>\n                                                <option value=\"France\">France<\/option>\n                                                <option value=\"French Guiana\">French Guiana<\/option>\n                                                <option value=\"French Polynesia\">French Polynesia<\/option>\n                                                <option value=\"French Southern Territories\">French Southern Territories\n                                                <\/option>\n                                                <option value=\"Gabon\">Gabon<\/option>\n                                                <option value=\"Gambia\">Gambia<\/option>\n                                                <option value=\"Georgia\">Georgia<\/option>\n                                                <option value=\"Germany\">Germany<\/option>\n                                                <option value=\"Ghana\">Ghana<\/option>\n                                                <option value=\"Gibraltar\">Gibraltar<\/option>\n                                                <option value=\"Greece\">Greece<\/option>\n                                                <option value=\"Greenland\">Greenland<\/option>\n                                                <option value=\"Grenada\">Grenada<\/option>\n                                                <option value=\"Guadeloupe\">Guadeloupe<\/option>\n                                                <option value=\"Guam\">Guam<\/option>\n                                                <option value=\"Guatemala\">Guatemala<\/option>\n                                                <option value=\"Guernsey\">Guernsey<\/option>\n                                                <option value=\"Guinea\">Guinea<\/option>\n                                                <option value=\"Guinea-Bissau\">Guinea-Bissau<\/option>\n                                                <option value=\"Guyana\">Guyana<\/option>\n                                                <option value=\"Haiti\">Haiti<\/option>\n                                                <option value=\"Heard and Mc Donald Islands\">Heard and Mc Donald Islands\n                                                <\/option>\n                                                <option value=\"Honduras\">Honduras<\/option>\n                                                <option value=\"Hong Kong\">Hong Kong<\/option>\n                                                <option value=\"Hungary\">Hungary<\/option>\n                                                <option value=\"Iceland\">Iceland<\/option>\n                                                <option value=\"India\">India<\/option>\n                                                <option value=\"Indonesia\">Indonesia<\/option>\n                                                <option value=\"Iran\">Iran<\/option>\n                                                <option value=\"Iraq\">Iraq<\/option>\n                                                <option value=\"Ireland\">Ireland<\/option>\n                                                <option value=\"Isle of Man\">Isle of Man<\/option>\n                                                <option value=\"Israel\">Israel<\/option>\n                                                <option value=\"Italy\">Italy<\/option>\n                                                <option value=\"Jamaica\">Jamaica<\/option>\n                                                <option value=\"Japan\">Japan<\/option>\n                                                <option value=\"Jersey  (Channel Islands)\">Jersey (Channel Islands)\n                                                <\/option>\n                                                <option value=\"Jordan\">Jordan<\/option>\n                                                <option value=\"Kazakhstan\">Kazakhstan<\/option>\n                                                <option value=\"Kenya\">Kenya<\/option>\n                                                <option value=\"Kiribati\">Kiribati<\/option>\n                                                <option value=\"Kuwait\">Kuwait<\/option>\n                                                <option value=\"Kyrgyzstan\">Kyrgyzstan<\/option>\n                                                <option value=\"Lao People's Democratic Republic\">Lao People&#8217;s Democratic\n                                                    Republic<\/option>\n                                                <option value=\"Latvia\">Latvia<\/option>\n                                                <option value=\"Lebanon\">Lebanon<\/option>\n                                                <option value=\"Lesotho\">Lesotho<\/option>\n                                                <option value=\"Liberia\">Liberia<\/option>\n                                                <option value=\"Libya\">Libya<\/option>\n                                                <option value=\"Liechtenstein\">Liechtenstein<\/option>\n                                                <option value=\"Lithuania\">Lithuania<\/option>\n                                                <option value=\"Luxembourg\">Luxembourg<\/option>\n                                                <option value=\"Macau\">Macau<\/option>\n                                                <option value=\"Macedonia\">Macedonia<\/option>\n                                                <option value=\"Madagascar\">Madagascar<\/option>\n                                                <option value=\"Malawi\">Malawi<\/option>\n                                                <option value=\"Malaysia\">Malaysia<\/option>\n                                                <option value=\"Maldives\">Maldives<\/option>\n                                                <option value=\"Mali\">Mali<\/option>\n                                                <option value=\"Malta\">Malta<\/option>\n                                                <option value=\"Marshall Islands\">Marshall Islands<\/option>\n                                                <option value=\"Martinique\">Martinique<\/option>\n                                                <option value=\"Mauritania\">Mauritania<\/option>\n                                                <option value=\"Mauritius\">Mauritius<\/option>\n                                                <option value=\"Mayotte\">Mayotte<\/option>\n                                                <option value=\"Mexico\">Mexico<\/option>\n                                                <option value=\"Micronesia, Federated States of\">Micronesia, Federated\n                                                    States\n                                                    of<\/option>\n                                                <option value=\"Moldova\">Moldova<\/option>\n                                                <option value=\"Monaco\">Monaco<\/option>\n                                                <option value=\"Mongolia\">Mongolia<\/option>\n                                                <option value=\"Montenegro\">Montenegro<\/option>\n                                                <option value=\"Montserrat\">Montserrat<\/option>\n                                                <option value=\"Morocco\">Morocco<\/option>\n                                                <option value=\"Mozambique\">Mozambique<\/option>\n                                                <option value=\"Myanmar\">Myanmar<\/option>\n                                                <option value=\"Namibia\">Namibia<\/option>\n                                                <option value=\"Nauru\">Nauru<\/option>\n                                                <option value=\"Nepal\">Nepal<\/option>\n                                                <option value=\"Netherlands\">Netherlands<\/option>\n                                                <option value=\"Netherlands Antilles\">Netherlands Antilles<\/option>\n                                                <option value=\"New Caledonia\">New Caledonia<\/option>\n                                                <option value=\"New Zealand\">New Zealand<\/option>\n                                                <option value=\"Nicaragua\">Nicaragua<\/option>\n                                                <option value=\"Niger\">Niger<\/option>\n                                                <option value=\"Nigeria\">Nigeria<\/option>\n                                                <option value=\"Niue\">Niue<\/option>\n                                                <option value=\"Norfolk Island\">Norfolk Island<\/option>\n                                                <option value=\"North Korea\">North Korea<\/option>\n                                                <option value=\"Northern Mariana Islands\">Northern Mariana Islands\n                                                <\/option>\n                                                <option value=\"Norway\">Norway<\/option>\n                                                <option value=\"Oman\">Oman<\/option>\n                                                <option value=\"Pakistan\">Pakistan<\/option>\n                                                <option value=\"Palau\">Palau<\/option>\n                                                <option value=\"Palestine\">Palestine<\/option>\n                                                <option value=\"Panama\">Panama<\/option>\n                                                <option value=\"Papua New Guinea\">Papua New Guinea<\/option>\n                                                <option value=\"Paraguay\">Paraguay<\/option>\n                                                <option value=\"Peru\">Peru<\/option>\n                                                <option value=\"Philippines\">Philippines<\/option>\n                                                <option value=\"Pitcairn\">Pitcairn<\/option>\n                                                <option value=\"Poland\">Poland<\/option>\n                                                <option value=\"Portugal\">Portugal<\/option>\n                                                <option value=\"Puerto Rico\">Puerto Rico<\/option>\n                                                <option value=\"Qatar\">Qatar<\/option>\n                                                <option value=\"Republic of Kosovo\">Republic of Kosovo<\/option>\n                                                <option value=\"Reunion\">Reunion<\/option>\n                                                <option value=\"Romania\">Romania<\/option>\n                                                <option value=\"Russia\">Russia<\/option>\n                                                <option value=\"Rwanda\">Rwanda<\/option>\n                                                <option value=\"Saint Kitts and Nevis\">Saint Kitts and Nevis<\/option>\n                                                <option value=\"Saint Lucia\">Saint Lucia<\/option>\n                                                <option value=\"Saint Martin\">Saint Martin<\/option>\n                                                <option value=\"Saint Vincent and the Grenadines\">Saint Vincent and the\n                                                    Grenadines<\/option>\n                                                <option value=\"Samoa (Independent)\">Samoa (Independent)<\/option>\n                                                <option value=\"San Marino\">San Marino<\/option>\n                                                <option value=\"Sao Tome and Principe\">Sao Tome and Principe<\/option>\n                                                <option value=\"Saudi Arabia\">Saudi Arabia<\/option>\n                                                <option value=\"Senegal\">Senegal<\/option>\n                                                <option value=\"Serbia\">Serbia<\/option>\n                                                <option value=\"Seychelles\">Seychelles<\/option>\n                                                <option value=\"Sierra Leone\">Sierra Leone<\/option>\n                                                <option value=\"Singapore\">Singapore<\/option>\n                                                <option value=\"Sint Maarten\">Sint Maarten<\/option>\n                                                <option value=\"Slovakia\">Slovakia<\/option>\n                                                <option value=\"Slovenia\">Slovenia<\/option>\n                                                <option value=\"Solomon Islands\">Solomon Islands<\/option>\n                                                <option value=\"Somalia\">Somalia<\/option>\n                                                <option value=\"South Africa\">South Africa<\/option>\n                                                <option value=\"South Georgia and the South Sandwich Islands\">South\n                                                    Georgia\n                                                    and the South Sandwich Islands<\/option>\n                                                <option value=\"South Korea\">South Korea<\/option>\n                                                <option value=\"South Sudan\">South Sudan<\/option>\n                                                <option value=\"Spain\">Spain<\/option>\n                                                <option value=\"Sri Lanka\">Sri Lanka<\/option>\n                                                <option value=\"St. Helena\">St. Helena<\/option>\n                                                <option value=\"St. Pierre and Miquelon\">St. Pierre and Miquelon<\/option>\n                                                <option value=\"Sudan\">Sudan<\/option>\n                                                <option value=\"Suriname\">Suriname<\/option>\n                                                <option value=\"Svalbard and Jan Mayen Islands\">Svalbard and Jan Mayen\n                                                    Islands<\/option>\n                                                <option value=\"Swaziland\">Swaziland<\/option>\n                                                <option value=\"Sweden\">Sweden<\/option>\n                                                <option value=\"Switzerland\">Switzerland<\/option>\n                                                <option value=\"Syria\">Syria<\/option>\n      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Kingdom<\/option>\n                                                <option value=\"Uruguay\">Uruguay<\/option>\n                                                <option value=\"USA Minor Outlying Islands\">USA Minor Outlying Islands\n                                                <\/option>\n                                                <option value=\"Uzbekistan\">Uzbekistan<\/option>\n                                                <option value=\"Vanuatu\">Vanuatu<\/option>\n                                                <option value=\"Vatican City State (Holy See)\">Vatican City State (Holy\n                                                    See)\n                                                <\/option>\n                                                <option value=\"Venezuela\">Venezuela<\/option>\n                                                <option value=\"Vietnam\">Vietnam<\/option>\n                                                <option value=\"Virgin Islands (British)\">Virgin Islands (British)\n                                                <\/option>\n                                                <option value=\"Virgin Islands (U.S.)\">Virgin Islands (U.S.)<\/option>\n                                                <option value=\"Wallis and Futuna Islands\">Wallis and Futuna Islands\n                                                <\/option>\n                                                <option value=\"Western Sahara\">Western Sahara<\/option>\n                                                <option value=\"Yemen\">Yemen<\/option>\n                                                <option value=\"Zambia\">Zambia<\/option>\n                                                <option value=\"Zimbabwe\">Zimbabwe<\/option>\n                                            <\/select>\n                                        <\/div>\n                                    <\/div>\n                                    <div id=\"mce-responses\" 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