Efficient constitution of a library of rotenoid analogs active against Trypanosoma cruzi from a digitalized plant extract collection

by Gaudry A, Marcourt L, Kaiser M, Flückiger J, David B, Grondin A, Ioset J-R, Mäser P, Queiroz EF, Allard P-M, Wolfender J-L. RSC Advances 2025; 15:15240–15251. doi: 10.1039/D4RA08652J.

Summary: The potent anti-Trypanosoma cruzi activity of two rotenoids, deguelin and rotenone, identified in six active extracts from four plant species, has recently been described. The authors of this manuscript describe the phytochemical investigation of four of these extracts and the establishment of a library of structural analogs for in vitro bioactivity testing. This work led to the isolation, characterization, and biological evaluation of the anti-T. cruzi potential of 41 compounds, including 11 rotenoids and seven compounds reported for the first time. Thanks to modern metabolite annotation and single-step isolation procedures, this work also demonstrates the possibility of considering natural extract libraries as a reservoir of rapidly accessible pure natural products.

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