by Barnadas-Carceller B, Tàssies D, Losada Galván I, Alonso-Padilla J, Carles Reverter J, Fernandez-Becerra C, Pinazo M-J. In: Gómez, K.A., Buscaglia, C.A. (eds). Methods in Molecular Biology 2026, 2982. Humana, New York, NY. doi: 10.1007/978-1-0716-4848-3_19
Summary: Due to the lack of reliable biomarkers for disease prognosis and treatment monitoring of Chagas disease, there has been growing interest in host-derived markers as alternatives. One area of focus is the hypercoagulability observed in individuals with T. cruzi infection, which increases the risk of thrombotic events. In addition, extracellular vesicles, which contain proteins, lipids, and nucleic acids that can provide valuable molecular information about a patient’s condition, have emerged as a potential source of biomarkers for disease detection, prognosis, and monitoring. This book chapter outlines procedures for detecting host-derived biomarkers of Chagas disease, particularly those related to hypercoagulability, and the isolation and characterization of extracellular vesicles as biomarkers for response to treatment and disease progression.
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