A scoping literature review of global dengue age-stratified seroprevalence data: estimating dengue force of infection in endemic countries

By Vicco V, McCormack C, Pedrique B, Ribeiro I, Malavige GN, Dorigatti I. eBioMedicine 2024, 104:105134. doi: 10.1016/j.ebiom.2024.105134

Summary: The authors of this scoping literature review updated a previous study of dengue transmission intensity by collating global age-stratified dengue seroprevalence data published in Medline, Embase and Web of Science from 2014 to 2023. These data were used to calibrate catalytic models and estimate the force of infection (FOI) – the yearly per-capita risk of infection for a typical susceptible individual. 66 publications contained 219 age-stratified seroprevalence datasets across 30 countries. Including previous data, there are now more than 250 dengue FOI estimates from seroprevalence studies worldwide. Large heterogeneities in average FOI are seen between and within countries.  These new estimates can inform modelling efforts to improve understanding of the heterogeneity in dengue transmission, and thus inform public health interventions.

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